MIAMI - Federal investigators are beginning work to determine why an Amazon cargo plane overran a runway at Miami International Airport, struck vehicles and caught fire. At least five people were killed and five others injured, officials said.

The aircraft arrived from San Juan, Puerto Rico, and left the runway at about 2 p.m. Sunday. It crossed a road used by warehouse workers and other businesses around the airport before becoming engulfed in flames. Three of the injured were critically hurt, while two others were taken to hospital with less serious injuries.

Rescue crews found the pilot and co-pilot trapped in the cockpit and had to free people from vehicles. A fuel leak complicated the response after the fire was extinguished. The crash forced the closure of the airport's runways for much of the afternoon.

The National Transportation Safety Board said its chairwoman, Jennifer Homendy, would hold a news conference on Monday. Investigators are expected to examine the approach, weather, wind and the point at which the aircraft touched down, among other factors.

Aviation experts told AP that an aircraft which lands too far along the runway may need to abort the landing and go around. Those comments are preliminary and do not establish the cause of the Miami crash, which will depend on the evidence gathered by investigators.